Setting description

Hormone therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Niraparib
— param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
–+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
-+- param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
-++ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
+– param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
+-+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
++- param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
+++ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Niraparib
all param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
TP53- param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 393 0 0
TP53- 335 0 0
TP53+ 338 2 1
DRD+ 193 1 0
TEfus+ 310 0 0
Hormone_therapies Taxel_therapies Niraparib
all 0.786 0.000 0.000
TP53- 0.670 0.000 0.000
TP53+ 0.676 0.004 0.002
DRD+ 0.386 0.002 0.000
TEfus+ 0.620 0.000 0.000
futility (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 0 211 252
TP53- 2 362 386
TP53+ 3 327 356
DRD+ 0 184 311
TEfus+ 3 307 339
Hormone_therapies Taxel_therapies Niraparib
all 0.000 0.422 0.504
TP53- 0.004 0.724 0.772
TP53+ 0.006 0.654 0.712
DRD+ 0.000 0.368 0.622
TEfus+ 0.006 0.614 0.678
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 0 0 0
TP53- 59 29 23
TP53+ 10 17 6
DRD+ 0 0 0
TEfus+ 0 0 0
Hormone_therapies Taxel_therapies Niraparib
all 0.000 0.000 0.000
TP53- 0.118 0.058 0.046
TP53+ 0.020 0.034 0.012
DRD+ 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000


Errors & power

The overall error was 0.17.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies         Niraparib 
            0.166             0.006             0.002

The overall power was 0.786.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies         Niraparib 
            0.786             0.000             0.000

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Niraparib
all graduation 0 393 0 0
futility 0 0 211 252
max_n 0 0 0 0
n 616 (456, 735) 325 (187, 517) 255 (133, 442) 232 (131, 409)
n_unique 616 (456, 735) 325 (187, 517) 255 (133, 442) 232 (131, 409)
time_trial 60 (60, 60) 40 (24, 60) 60 (31, 60) 60 (27, 60)
time_stop NA (NA, NA) 35 (23, 53) 41 (18, 57) 39 (23, 56)
post_p NA (NA, NA) 1 (1, 1) 0.02 (0, 0.18) 0.02 (0, 0.19)
rate 0.017 (0.016, 0.019) 0.011 (0.01, 0.012) 0.022 (0.02, 0.025) 0.022 (0.019, 0.025)
TP53- graduation 0 335 0 0
futility 0 2 362 386
max_n 0 59 29 23
n 344 (214, 413) 176 (100, 301) 117 (52, 283) 112 (54, 270)
n_unique 344 (214, 413) 176 (100, 301) 117 (52, 283) 112 (54, 270)
time_trial 60 (60, 60) 46 (27, 60) 42 (20, 60) 37 (18, 60)
time_stop NA (NA, NA) 37 (26, 55) 34 (18, 54) 30 (17, 52)
post_p NA (NA, NA) 1 (0.98, 1) 0.07 (0, 0.34) 0.06 (0, 0.37)
rate 0.017 (0.016, 0.019) 0.011 (0.01, 0.013) 0.022 (0.019, 0.027) 0.022 (0.019, 0.027)
TP53+ graduation 0 338 2 1
futility 0 3 327 356
max_n 0 10 17 6
n 292 (179, 351) 128 (75, 245) 108 (53, 238) 94 (52, 223)
n_unique 292 (179, 351) 128 (75, 245) 108 (53, 238) 94 (52, 223)
time_trial 60 (60, 60) 48 (29, 60) 44 (20, 60) 40 (21, 60)
time_stop NA (NA, NA) 40 (26, 55) 33 (18, 53) 32 (20, 52)
post_p NA (NA, NA) 1 (0.96, 1) 0.07 (0, 0.42) 0.09 (0, 0.38)
rate 0.017 (0.015, 0.019) 0.011 (0.009, 0.013) 0.022 (0.019, 0.027) 0.022 (0.019, 0.027)
DRD+ graduation 0 193 1 0
futility 0 0 184 311
max_n 0 0 0 0
n 160 (106, 206) 72 (41, 121) 74 (34, 134) 65 (48, 130)
n_unique 160 (106, 206) 72 (41, 121) 74 (34, 134) 65 (48, 130)
time_trial 60 (60, 60) 60 (36, 60) 60 (39, 60) 46 (21, 60)
time_stop NA (NA, NA) 43 (31, 57) 46 (34, 57) 30 (20, 54)
post_p NA (NA, NA) 0.98 (0.86, 1) 0.14 (0.01, 0.52) 0.12 (0.01, 0.51)
rate 0.017 (0.015, 0.02) 0.011 (0.009, 0.014) 0.021 (0.018, 0.028) 0.023 (0.019, 0.028)
TEfus+ graduation 0 310 0 0
futility 0 3 307 339
max_n 0 0 0 0
n 213 (139, 271) 99 (60, 178) 86 (50, 178) 79 (50, 160)
n_unique 213 (139, 271) 99 (60, 178) 86 (50, 178) 79 (50, 160)
time_trial 60 (60, 60) 52 (31, 60) 49 (24, 60) 44 (23, 60)
time_stop NA (NA, NA) 41 (29, 57) 35 (23, 53) 34 (21, 53)
post_p NA (NA, NA) 0.99 (0.91, 1) 0.1 (0, 0.43) 0.09 (0.01, 0.43)
rate 0.017 (0.015, 0.02) 0.011 (0.009, 0.013) 0.022 (0.019, 0.027) 0.022 (0.019, 0.028)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Niraparib
— graduation 0 433 387 397
futility 0 0 0 0
max_n 0 47 29 23
n 199 (122, 243) 108 (59, 194) 54 (22, 159) 52 (19, 156)
n_unique 199 (122, 243) 108 (59, 194) 54 (22, 159) 52 (19, 156)
post_p NA (NA, NA) 0.99 (0.89, 1) 0.15 (0.01, 0.53) 0.15 (0.02, 0.53)
rate 0.017 (0.015, 0.02) 0.011 (0.009, 0.014) 0.022 (0.018, 0.029) 0.022 (0.018, 0.029)
–+ graduation 0 451 422 433
futility 0 0 0 0
max_n 0 41 28 22
n 50 (27, 68) 24 (12, 47) 18 (10, 53) 16 (7, 48)
n_unique 50 (27, 68) 24 (12, 47) 18 (10, 53) 16 (7, 48)
post_p NA (NA, NA) 0.88 (0.59, 0.99) 0.23 (0.04, 0.66) 0.25 (0.05, 0.65)
rate 0.017 (0.013, 0.022) 0.011 (0.007, 0.016) 0.023 (0.016, 0.035) 0.023 (0.016, 0.036)
-+- graduation 0 439 351 382
futility 0 0 0 0
max_n 0 6 17 6
n 132 (78, 159) 60 (30, 122) 40 (20, 116) 37 (15, 111)
n_unique 132 (78, 159) 60 (30, 122) 40 (20, 116) 37 (15, 111)
post_p NA (NA, NA) 0.96 (0.77, 1) 0.17 (0.02, 0.57) 0.21 (0.02, 0.6)
rate 0.017 (0.014, 0.02) 0.011 (0.008, 0.014) 0.022 (0.018, 0.029) 0.022 (0.017, 0.03)
-++ graduation 0 455 421 435
futility 0 0 0 0
max_n 0 6 17 5
n 86 (48, 113) 39 (21, 80) 27 (16, 79) 24 (11, 75)
n_unique 86 (48, 113) 39 (21, 80) 27 (16, 79) 24 (11, 75)
post_p NA (NA, NA) 0.94 (0.66, 1) 0.21 (0.03, 0.59) 0.23 (0.04, 0.61)
rate 0.017 (0.014, 0.021) 0.011 (0.008, 0.015) 0.022 (0.017, 0.03) 0.023 (0.016, 0.032)
+– graduation 0 440 415 441
futility 0 0 0 0
max_n 0 47 28 22
n 46 (27, 63) 20 (9, 38) 20 (6, 46) 17 (10, 43)
n_unique 46 (27, 63) 20 (9, 38) 20 (6, 46) 17 (10, 43)
post_p NA (NA, NA) 0.86 (0.5, 0.98) 0.28 (0.07, 0.62) 0.25 (0.05, 0.65)
rate 0.017 (0.013, 0.022) 0.011 (0.006, 0.017) 0.023 (0.015, 0.034) 0.023 (0.016, 0.034)
+-+ graduation 0 457 438 458
futility 0 0 0 0
max_n 0 41 28 21
n 43 (24, 63) 19 (9, 38) 14 (5, 44) 16 (9, 42)
n_unique 43 (24, 63) 19 (9, 38) 14 (5, 44) 16 (9, 42)
post_p NA (NA, NA) 0.86 (0.54, 0.98) 0.3 (0.06, 0.66) 0.26 (0.05, 0.66)
rate 0.018 (0.013, 0.023) 0.011 (0.006, 0.017) 0.023 (0.015, 0.038) 0.023 (0.016, 0.034)
++- graduation 0 444 374 423
futility 0 0 0 0
max_n 0 6 17 5
n 37 (19, 51) 14 (7, 32) 15 (5, 39) 14 (8, 36)
n_unique 37 (19, 51) 14 (7, 32) 15 (5, 39) 14 (8, 36)
post_p NA (NA, NA) 0.81 (0.48, 0.97) 0.34 (0.08, 0.71) 0.3 (0.06, 0.67)
rate 0.018 (0.013, 0.024) 0.011 (0.006, 0.018) 0.022 (0.013, 0.037) 0.023 (0.016, 0.036)
+++ graduation 0 459 428 453
futility 0 0 0 0
max_n 0 6 17 5
n 33 (19, 50) 14 (7, 28) 13 (4, 36) 13 (8, 33)
n_unique 33 (19, 50) 14 (7, 28) 13 (4, 36) 13 (8, 33)
post_p NA (NA, NA) 0.81 (0.46, 0.97) 0.32 (0.08, 0.69) 0.27 (0.06, 0.64)
rate 0.017 (0.012, 0.023) 0.011 (0.005, 0.018) 0.022 (0.014, 0.036) 0.023 (0.016, 0.037)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Niraparib
all count 393
time_stop 35 (23, 53)
n_trt 289 (179, 464)
n_control 396 (240, 601)
post_p 1 (0.97, 1)
order 2 (1, 3)
TP53- count 335
time_stop 38 (26, 55)
n_trt 156 (98, 260)
n_control 230 (147, 341)
post_p 0.99 (0.95, 1)
order 2 (1, 4)
TP53+ count 338 2 1
time_stop 40 (27, 55) 39 (31, 47) 33 (33, 33)
n_trt 118 (76, 202) 106 (96, 115) 93 (93, 93)
n_control 193 (126, 284) 216 (181, 252) 174 (174, 174)
post_p 0.99 (0.95, 1) 0.95 (0.91, 0.98) 0.98 (0.98, 0.98)
order 2 (1, 4) 2 (2, 2) 1 (1, 1)
DRD+ count 193 1
time_stop 43 (31, 57) 41 (41, 41)
n_trt 73 (55, 115) 71 (71, 71)
n_control 125 (89, 172) 111 (111, 111)
post_p 0.99 (0.94, 1) 0.98 (0.98, 0.98)
order 3 (1, 5) 2 (2, 2)
TEfus+ count 310
time_stop 41 (29, 57)
n_trt 95 (62, 163)
n_control 162 (111, 233)
post_p 0.99 (0.95, 1)
order 3 (1, 5)
Futility:
signature var Hormone_therapies Taxel_therapies Niraparib
all count 211 252
time_stop 41 (18, 57) 39 (23, 56)
n_trt 183 (101, 315) 177 (115, 309)
n_control 439 (176, 608) 431 (233, 586)
post_p 0.02 (0, 0.12) 0.02 (0, 0.1)
order 5 (1, 8) 4 (2, 7)
TP53- count 2 362 386
time_stop 21 (14, 28) 34 (18, 54) 30 (17, 52)
n_trt 91 (63, 119) 95 (55, 220) 93 (54, 206)
n_control 125 (79, 171) 207 (98, 353) 177 (92, 327)
post_p 0.28 (0.26, 0.29) 0.1 (0.01, 0.24) 0.11 (0.02, 0.26)
order 1.5 (1.1, 1.9) 3 (1, 6) 3 (1, 7)
TP53+ count 3 327 356
time_stop 22 (20, 29) 33 (18, 53) 32 (20, 52)
n_trt 53 (52, 91) 83 (53, 175) 80 (53, 166)
n_control 114 (95, 142) 167 (82, 286) 154 (92, 270)
post_p 0.24 (0.18, 0.29) 0.1 (0.02, 0.24) 0.12 (0.02, 0.25)
order 1 (1, 1.8) 3 (1, 7) 3 (1, 7)
DRD+ count 184 311
time_stop 46 (34, 57) 30 (20, 54)
n_trt 71 (52, 107) 60 (50, 105)
n_control 130 (98, 175) 91 (54, 162)
post_p 0.09 (0.01, 0.24) 0.13 (0.03, 0.27)
order 6 (3, 9) 3 (1, 7)
TEfus+ count 3 307 339
time_stop 29 (21, 38) 35 (23, 53) 34 (21, 53)
n_trt 60 (52, 63) 72 (52, 129) 69 (51, 129)
n_control 95 (95, 145) 143 (85, 221) 132 (77, 214)
post_p 0.19 (0.04, 0.22) 0.1 (0.02, 0.23) 0.12 (0.02, 0.26)
order 3 (2.2, 3) 4 (2, 8) 4 (1, 7)


By subgroup combinations

Graduation:
signature treatment var — –+ -+- -++ +– +-+ ++- +++
all Hormone_therapies count 393 393 393 393 393 393 393 393
time 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53)
n 98 (57, 173) 23 (12, 43) 54 (29, 101) 36 (20, 71) 19 (9, 34) 18 (9, 34) 13 (7, 26) 13 (7, 25)
post_p 0.92 (0.65, 1) 0.72 (0.57, 0.94) 0.86 (0.6, 0.99) 0.81 (0.58, 0.97) 0.69 (0.57, 0.94) 0.73 (0.57, 0.93) 0.66 (0.56, 0.9) 0.66 (0.56, 0.89)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.01 (0.006, 0.013) 0.009 (0, 0.014) 0.009 (0.005, 0.014) 0.009 (0.004, 0.014) 0.009 (0, 0.015) 0.008 (0, 0.015) 0.008 (0, 0.015) 0.008 (0, 0.015)
TP53- count 335 335 335 335
time 38 (26, 55) 38 (26, 55) 38 (26, 55) 38 (26, 55)
n 96 (58, 163) 23 (12, 41) 18 (9, 34) 18 (8, 33)
post_p 0.93 (0.74, 1) 0.78 (0.7, 0.94) 0.76 (0.66, 0.93) 0.78 (0.65, 0.96)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0 (0, 0) 0 (0, 0)
rate 0.01 (0.007, 0.013) 0.008 (0.002, 0.013) 0.008 (0, 0.013) 0.008 (0, 0.013)
TP53+ count 338 338 338 338
time 40 (27, 55) 40 (27, 55) 40 (27, 55) 40 (27, 55)
n 54 (30, 96) 37 (21, 69) 13 (7, 26) 13 (7, 25)
post_p 0.88 (0.72, 0.99) 0.84 (0.72, 0.98) 0.74 (0.62, 0.92) 0.74 (0.61, 0.91)
r_prob 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.01 (0.005, 0.013) 0.009 (0.004, 0.013) 0.008 (0, 0.013) 0.007 (0, 0.013)
Taxel_therapies count 2 2 2 2
time 39 (31, 47) 39 (31, 47) 39 (31, 47) 39 (31, 47)
n 54 (49, 58) 22 (22, 22) 13 (11, 15) 17 (10, 24)
post_p 0.9 (0.88, 0.91) 0.73 (0.72, 0.73) 0.7 (0.63, 0.77) 0.66 (0.61, 0.7)
r_prob 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.013 (0.01, 0.016) 0.014 (0.011, 0.016) 0.008 (0.006, 0.011) 0.011 (0.011, 0.011)
Niraparib count 1 1 1 1
time 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33)
n 42 (42, 42) 16 (16, 16) 16 (16, 16) 19 (19, 19)
post_p 0.73 (0.73, 0.73) 0.7 (0.7, 0.7) 0.77 (0.77, 0.77) 0.71 (0.71, 0.71)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.011 (0.011, 0.011) 0.014 (0.014, 0.014) 0.003 (0.003, 0.003) 0.004 (0.004, 0.004)
DRD+ Hormone_therapies count 193 193 193 193
time 43 (31, 57) 43 (31, 57) 43 (31, 57) 43 (31, 57)
n 22 (11, 37) 21 (13, 36) 15 (8, 27) 14 (8, 26)
post_p 0.82 (0.71, 0.97) 0.81 (0.71, 0.97) 0.76 (0.65, 0.92) 0.75 (0.65, 0.93)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.004, 0.013) 0.008 (0.003, 0.014) 0.008 (0, 0.014) 0.008 (0, 0.014)
Taxel_therapies count 1 1 1 1
time 41 (41, 41) 41 (41, 41) 41 (41, 41) 41 (41, 41)
n 37 (37, 37) 23 (23, 23) 7 (7, 7) 4 (4, 4)
post_p 0.73 (0.73, 0.73) 0.93 (0.93, 0.93) 0.6 (0.6, 0.6) 0.62 (0.62, 0.62)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.009, 0.009) 0.009 (0.009, 0.009) 0.012 (0.012, 0.012) 0.011 (0.011, 0.011)
TEfus+ Hormone_therapies count 310 310 310 310
time 41 (29, 57) 41 (29, 57) 41 (29, 57) 41 (29, 57)
n 24 (14, 44) 37 (22, 71) 20 (9, 36) 14 (7, 25)
post_p 0.79 (0.71, 0.95) 0.88 (0.72, 0.99) 0.79 (0.7, 0.97) 0.74 (0.63, 0.92)
r_prob 0.19 (0.19, 0.19) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.004, 0.013) 0.009 (0.005, 0.013) 0.008 (0, 0.014) 0.007 (0, 0.013)
Futility:
signature treatment var — –+ -+- -++ +– +-+ ++- +++
all Taxel_therapies count 211 211 211 211 211 211 211 211
time 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57)
n 41 (21, 122) 16 (8, 35) 31 (18, 84) 23 (14, 49) 13 (4, 37) 11 (5, 31) 9 (3, 25) 9 (3, 23)
post_p 0.25 (0.03, 0.46) 0.3 (0.07, 0.46) 0.21 (0.02, 0.45) 0.26 (0.05, 0.46) 0.35 (0.11, 0.49) 0.36 (0.1, 0.48) 0.39 (0.12, 0.48) 0.38 (0.11, 0.48)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.016, 0.029) 0.023 (0.016, 0.036) 0.022 (0.016, 0.029) 0.022 (0.015, 0.03) 0.022 (0.015, 0.038) 0.023 (0.014, 0.044) 0.023 (0.013, 0.044) 0.023 (0.014, 0.038)
Niraparib count 252 252 252 252 252 252 252 252
time 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56)
n 38 (17, 107) 13 (6, 37) 30 (14, 77) 20 (10, 51) 15 (10, 29) 15 (9, 27) 12 (8, 24) 12 (7, 20)
post_p 0.23 (0.04, 0.46) 0.35 (0.1, 0.47) 0.29 (0.06, 0.47) 0.32 (0.06, 0.48) 0.27 (0.07, 0.47) 0.3 (0.09, 0.46) 0.32 (0.11, 0.47) 0.34 (0.09, 0.47)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.02 (0.015, 0.029) 0.023 (0.015, 0.041) 0.021 (0.016, 0.03) 0.022 (0.015, 0.033) 0.023 (0.014, 0.035) 0.023 (0.016, 0.035) 0.023 (0.013, 0.036) 0.023 (0.013, 0.037)
TP53- Hormone_therapies count 2 2 2 2
time 21 (14, 28) 21 (14, 28) 21 (14, 28) 21 (14, 28)
n 66 (43, 88) 12 (8, 15) 8 (8, 8) 6 (4, 8)
post_p 0.39 (0.33, 0.45) 0.48 (0.47, 0.5) 0.43 (0.42, 0.44) 0.43 (0.4, 0.47)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0 (0, 0) 0 (0, 0)
rate 0.014 (0.012, 0.016) 0.008 (0.002, 0.014) 0.03 (0.025, 0.035) 0.01 (0.002, 0.018)
Taxel_therapies count 362 362 362 362
time 34 (18, 54) 34 (18, 54) 34 (18, 54) 34 (18, 54)
n 44 (24, 128) 17 (10, 41) 15 (6, 39) 13 (6, 36)
post_p 0.25 (0.04, 0.46) 0.33 (0.1, 0.47) 0.41 (0.16, 0.49) 0.41 (0.16, 0.49)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.015, 0.027) 0.021 (0.014, 0.034) 0.022 (0.015, 0.04) 0.022 (0.014, 0.037)
Niraparib count 386 386 386 386
time 30 (17, 52) 30 (17, 52) 30 (17, 52) 30 (17, 52)
n 39 (18, 126) 14 (7, 40) 16 (10, 35) 15 (9, 30)
post_p 0.31 (0.06, 0.47) 0.41 (0.14, 0.49) 0.36 (0.12, 0.48) 0.36 (0.16, 0.48)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.019 (0.014, 0.027) 0.021 (0.013, 0.042) 0.021 (0.013, 0.035) 0.02 (0.013, 0.034)
TP53+ Hormone_therapies count 3 3 3 3
time 22 (20, 29) 22 (20, 29) 22 (20, 29) 22 (20, 29)
n 27 (18, 42) 22 (19, 24) 4 (3, 6) 12 (5, 22)
post_p 0.47 (0.41, 0.48) 0.44 (0.38, 0.49) 0.37 (0.28, 0.4) 0.47 (0.46, 0.48)
r_prob 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.012 (0.011, 0.02) 0.022 (0.019, 0.022) 0.081 (0.037, 0.128) 0.017 (0.012, 0.028)
Taxel_therapies count 327 327 327 327
time 33 (18, 53) 33 (18, 53) 33 (18, 53) 33 (18, 53)
n 32 (20, 83) 24 (16, 59) 11 (5, 27) 10 (4, 25)
post_p 0.27 (0.05, 0.46) 0.3 (0.09, 0.46) 0.43 (0.19, 0.49) 0.43 (0.25, 0.49)
r_prob 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.014, 0.029) 0.02 (0.014, 0.029) 0.023 (0.014, 0.046) 0.022 (0.013, 0.042)
Niraparib count 356 356 356 356
time 32 (20, 52) 32 (20, 52) 32 (20, 52) 32 (20, 52)
n 31 (15, 77) 21 (11, 57) 13 (8, 26) 12 (8, 22)
post_p 0.34 (0.09, 0.48) 0.37 (0.11, 0.48) 0.36 (0.15, 0.48) 0.38 (0.12, 0.48)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.02 (0.014, 0.029) 0.02 (0.014, 0.032) 0.022 (0.013, 0.036) 0.021 (0.012, 0.036)
DRD+ Taxel_therapies count 184 184 184 184
time 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57)
n 22 (8, 41) 18 (7, 41) 14 (5, 29) 13 (5, 28)
post_p 0.32 (0.11, 0.49) 0.3 (0.08, 0.47) 0.35 (0.13, 0.47) 0.36 (0.11, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.021 (0.015, 0.034) 0.023 (0.015, 0.037) 0.023 (0.016, 0.04) 0.023 (0.015, 0.04)
Niraparib count 311 311 311 311
time 30 (20, 54) 30 (20, 54) 30 (20, 54) 30 (20, 54)
n 17 (11, 35) 16 (10, 33) 14 (8, 28) 13 (8, 24)
post_p 0.36 (0.11, 0.48) 0.36 (0.13, 0.48) 0.4 (0.18, 0.48) 0.38 (0.14, 0.48)
r_prob 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.021 (0.012, 0.034) 0.02 (0.014, 0.031) 0.021 (0.012, 0.034) 0.022 (0.012, 0.036)
TEfus+ Hormone_therapies count 3 3 3 3
time 29 (21, 38) 29 (21, 38) 29 (21, 38) 29 (21, 38)
n 9 (9, 11) 21 (15, 33) 12 (10, 14) 10 (6, 20)
post_p 0.39 (0.2, 0.43) 0.5 (0.13, 0.5) 0.31 (0.13, 0.44) 0.45 (0.45, 0.49)
r_prob 0.19 (0.19, 0.19) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.025 (0.022, 0.025) 0.013 (0.011, 0.024) 0.024 (0.022, 0.027) 0.02 (0.016, 0.034)
Taxel_therapies count 307 307 307 307
time 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53)
n 18 (11, 38) 25 (16, 58) 13 (6, 34) 12 (5, 26)
post_p 0.31 (0.09, 0.48) 0.28 (0.07, 0.46) 0.4 (0.13, 0.48) 0.41 (0.2, 0.49)
r_prob 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.022 (0.014, 0.033) 0.02 (0.014, 0.028) 0.022 (0.014, 0.037) 0.022 (0.014, 0.041)
Niraparib count 339 339 339 339
time 34 (21, 53) 34 (21, 53) 34 (21, 53) 34 (21, 53)
n 15 (7, 39) 23 (12, 58) 16 (10, 30) 12 (8, 22)
post_p 0.39 (0.14, 0.49) 0.38 (0.11, 0.48) 0.33 (0.1, 0.47) 0.36 (0.11, 0.48)
r_prob 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.021 (0.014, 0.04) 0.019 (0.014, 0.03) 0.022 (0.014, 0.034) 0.022 (0.013, 0.036)